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An Adaptive Biosystems Engineering Approach towards Modeling the Soluble-to-Insoluble Phase Transition of Clofazimine

Clofazimine (CFZ) is a weakly basic, small-molecule antibiotic used for the treatment of mycobacterial infections including leprosy and multidrug-resistant tuberculosis. Upon prolonged oral administration, CFZ precipitates and accumulates within macrophages throughout the host. To model the pharmaco...

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Detalles Bibliográficos
Autores principales:	Willmer, Andrew R., Dunne, Steven, Swanson, Rosemary, Almeida, Deepak, Ammerman, Nicole C., Stringer, Kathleen A., Capparelli, Edmund V., Rosania, Gus R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779763/ https://www.ncbi.nlm.nih.gov/pubmed/35056913 http://dx.doi.org/10.3390/pharmaceutics14010017

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