The Effect of VPA Treatment on Radiolabeled DOTATATE Uptake: Differences Observed In Vitro and In Vivo

Background: To improve peptide receptor radionuclide therapy (PRRT), we aimed to enhance the expression of somatostatin type-2 receptors (SSTR2) in vitro and in vivo, using valproic acid (VPA). Methods: Human NCI-H69 small-cell lung carcinoma cells were treated with VPA, followed by [(111)In]In-DOTA...

Descripción completa

Detalles Bibliográficos
Autores principales: Klomp, Maria J., Hofland, Leo J., van den Brink, Lilian, van Koetsveld, Peter M., Dogan, Fadime, de Ridder, Corrina M. A., Stuurman, Debra C., Clahsen-van Groningen, Marian C., de Jong, Marion, Dalm, Simone U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779846/
https://www.ncbi.nlm.nih.gov/pubmed/35057069
http://dx.doi.org/10.3390/pharmaceutics14010173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779846/
https://www.ncbi.nlm.nih.gov/pubmed/35057069
http://dx.doi.org/10.3390/pharmaceutics14010173

Ejemplares similares