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The Effect of VPA Treatment on Radiolabeled DOTATATE Uptake: Differences Observed In Vitro and In Vivo

Background: To improve peptide receptor radionuclide therapy (PRRT), we aimed to enhance the expression of somatostatin type-2 receptors (SSTR2) in vitro and in vivo, using valproic acid (VPA). Methods: Human NCI-H69 small-cell lung carcinoma cells were treated with VPA, followed by [(111)In]In-DOTA...

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Detalles Bibliográficos
Autores principales:	Klomp, Maria J., Hofland, Leo J., van den Brink, Lilian, van Koetsveld, Peter M., Dogan, Fadime, de Ridder, Corrina M. A., Stuurman, Debra C., Clahsen-van Groningen, Marian C., de Jong, Marion, Dalm, Simone U.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779846/ https://www.ncbi.nlm.nih.gov/pubmed/35057069 http://dx.doi.org/10.3390/pharmaceutics14010173

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