Cu(II) Binding Increases the Soluble Toxicity of Amyloidogenic Light Chains

Light chain amyloidosis (AL) is caused by the aberrant overproduction of immunoglobulin light chains (LCs). The resulting abnormally high LC concentrations in blood lead to deposit formation in the heart and other target organs. Organ damage is caused not only by the accumulation of bulky amyloid de...

Descripción completa

Detalles Bibliográficos
Autores principales: Russo, Rosaria, Romeo, Margherita, Schulte, Tim, Maritan, Martina, Oberti, Luca, Barzago, Maria Monica, Barbiroli, Alberto, Pappone, Carlo, Anastasia, Luigi, Palladini, Giovanni, Diomede, Luisa, Ricagno, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780072/
https://www.ncbi.nlm.nih.gov/pubmed/35055136
http://dx.doi.org/10.3390/ijms23020950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780072/
https://www.ncbi.nlm.nih.gov/pubmed/35055136
http://dx.doi.org/10.3390/ijms23020950

Ejemplares similares