Cargando…

Cu(II) Binding Increases the Soluble Toxicity of Amyloidogenic Light Chains

Light chain amyloidosis (AL) is caused by the aberrant overproduction of immunoglobulin light chains (LCs). The resulting abnormally high LC concentrations in blood lead to deposit formation in the heart and other target organs. Organ damage is caused not only by the accumulation of bulky amyloid de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Russo, Rosaria, Romeo, Margherita, Schulte, Tim, Maritan, Martina, Oberti, Luca, Barzago, Maria Monica, Barbiroli, Alberto, Pappone, Carlo, Anastasia, Luigi, Palladini, Giovanni, Diomede, Luisa, Ricagno, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780072/ https://www.ncbi.nlm.nih.gov/pubmed/35055136 http://dx.doi.org/10.3390/ijms23020950

Ejemplares similares

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity
por: Oberti, Luca, et al.
Publicado: (2017)

Caenorhabditis elegans Models to Investigate the Mechanisms Underlying Tau Toxicity in Tauopathies
por: Natale, Carmina, et al.
Publicado: (2020)

Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis
por: de Rosa, Matteo, et al.
Publicado: (2015)

Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity
por: Garofalo, Maura, et al.
Publicado: (2021)

C. elegans detects toxicity of traumatic brain injury generated tau
por: Zanier, Elisa R., et al.
Publicado: (2021)

HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders
por: Zeinolabediny, Yasmin, et al.
Publicado: (2017)

Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells
por: Imperlini, Esther, et al.
Publicado: (2017)

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β(2)-Microglobulin
por: Halabelian, Levon, et al.
Publicado: (2014)

A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers In Vivo
por: Natale, Carmina, et al.
Publicado: (2022)

SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers
por: Shea, Dylan, et al.
Publicado: (2022)

Resolving the soluble-to-toxic transformation of amyloidogenic proteins: A method to assess intervention by small-molecules
por: Ahlawat, Jyoti, et al.
Publicado: (2023)

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient
por: Swuec, Paolo, et al.
Publicado: (2019)

Prediction of Amyloidogenic and Disordered Regions in Protein Chains
por: Galzitskaya, Oxana V, et al.
Publicado: (2006)

Protease‐sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation
por: Mazzini, Giulia, et al.
Publicado: (2021)

Cytotoxicity of amyloidogenic immunoglobulin light chains in cell culture
por: Sikkink, L A, et al.
Publicado: (2010)

Amyloidogenic light chains impair plasma cell survival
por: Pick, Marjorie, et al.
Publicado: (2023)

Role of mutations in the cellular internalization of amyloidogenic light chains into cardiomyocytes
por: Levinson, Rebecca T., et al.
Publicado: (2013)

PEGylated-nanoliposomal clusterin for amyloidogenic light chain-induced endothelial dysfunction
por: Guzman-Villanueva, Diana, et al.
Publicado: (2017)

Molecular mechanism of amyloidogenic mutations in hypervariable regions of antibody light chains
por: Rottenaicher, Georg J., et al.
Publicado: (2021)

Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid‐β 1‐42
por: Vadukul, Devkee M., et al.
Publicado: (2017)

Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains
por: Hora, Manuel, et al.
Publicado: (2017)

Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains
por: Sternke-Hoffmann, Rebecca, et al.
Publicado: (2023)

Glycosylation Tunes Neuroserpin Physiological and Pathological Properties
por: Visentin, Cristina, et al.
Publicado: (2020)

Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein
por: Bonì, Francesco, et al.
Publicado: (2018)

A covalent homodimer probing early oligomers along amyloid aggregation
por: Halabelian, Levon, et al.
Publicado: (2015)

Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity
por: Guan, Jian, et al.
Publicado: (2015)

Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity
por: Guan, Jian, et al.
Publicado: (2014)

Analysis of gene expression profiling of amyloidogenic immunoglobulin light-chains on cultured rat cardiomyocytes
por: Xu, Fei, et al.
Publicado: (2020)

Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant
por: Bonì, Francesco, et al.
Publicado: (2016)

Exploiting heterogeneous features to improve in silico prediction of peptide status – amyloidogenic or non-amyloidogenic
por: Nair, Smitha Sunil Kumaran, et al.
Publicado: (2011)

Toxic oligomers of the amyloidogenic HypF-N protein form pores in mitochondrial membranes
por: Farrugia, Maria Ylenia, et al.
Publicado: (2020)

Amyloidogenic determinants are usually not buried
por: Frousios, Kimon K, et al.
Publicado: (2009)

The Diagnostic Potential of Amyloidogenic Proteins
por: Jin, Yiyun, et al.
Publicado: (2021)

Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit
por: Diomede, Luisa, et al.
Publicado: (2013)

Hsp70 and Antifibrillogenic Peptides Promote Degradation and Inhibit Intracellular Aggregation of Amyloidogenic Light Chains
por: Dul, Jeanne L., et al.
Publicado: (2001)

Extremely Amyloidogenic Single-Chain Analogues of Insulin’s H-Fragment: Structural Adaptability of an Amyloid Stretch
por: Dec, Robert, et al.
Publicado: (2020)

AB-Amy: machine learning aided amyloidogenic risk prediction of therapeutic antibody light chains
por: Zhou, Yuwei, et al.
Publicado: (2023)

Autoimmune Responses to Soluble Aggregates of Amyloidogenic Proteins Involved in Neurodegenerative Diseases: Overlapping Aggregation Prone and Autoimmunogenic regions
por: Kumar, Sandeep, et al.
Publicado: (2016)

Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2‐microglobulin
por: Leri, Manuela, et al.
Publicado: (2016)

Transthyretin and BRICHOS: The Paradox of Amyloidogenic Proteins with Anti-Amyloidogenic Activity for Aβ in the Central Nervous System
por: Buxbaum, Joel N., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_95nd07262ph50pbcj7ed0ca19o