Methotrexate Disposition, Anti-Folate Activity, and Metabolomic Profiling to Identify Molecular Markers of Disease Activity and Drug Response in the Collagen-Induced Arthritis Mouse Model

Methotrexate (MTX) is widely used in the treatment of autoimmune arthritis but is limited by its unpredictable and variable response profile. Currently, no biomarkers exist to predict or monitor early therapeutic responses to MTX. Using a collagen-induced arthritis (CIA) mouse model, this study aime...

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Detalles Bibliográficos
Autores principales: Salamoun, Yezan M., Polireddy, Kishore, Cho, Yu Kyoung, Medcalf, Matthew R., Funk, Ryan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780148/
https://www.ncbi.nlm.nih.gov/pubmed/35050146
http://dx.doi.org/10.3390/metabo12010024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780148/
https://www.ncbi.nlm.nih.gov/pubmed/35050146
http://dx.doi.org/10.3390/metabo12010024

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