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Domain 2 of Hepatitis C Virus Protein NS5A Activates Glucokinase and Induces Lipogenesis in Hepatocytes
Hepatitis C virus (HCV) relies on cellular lipid metabolism for its replication, and actively modulates lipogenesis and lipid trafficking in infected hepatocytes. This translates into an intracellular accumulation of triglycerides leading to liver steatosis, cirrhosis and hepatocellular carcinoma, w...
Autores principales: | Perrin-Cocon, Laure, Kundlacz, Cindy, Jacquemin, Clémence, Hanoulle, Xavier, Aublin-Gex, Anne, Figl, Marianne, Manteca, Jeremy, André, Patrice, Vidalain, Pierre-Olivier, Lotteau, Vincent, Diaz, Olivier |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780509/ https://www.ncbi.nlm.nih.gov/pubmed/35055105 http://dx.doi.org/10.3390/ijms23020919 |
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