Anticancer Activity of Urease Mimetic Cobalt (III) Complexes on A549-Lung Cancer Cells: Targeting the Acidic Microenvironment

Tumour cells maintain a local hypoxic and acidic microenvironment which plays a crucial role in cancer progression and drug resistance. Urease is a metallohydrolases that catalyses the hydrolysis of urea into ammonia and carbon dioxide, causing an abrupt increase of pH. This enzymatic activity can b...

Descripción completa

Detalles Bibliográficos
Autores principales: Uprety, Bhawna, Chandran, Rahul, Arderne, Charmaine, Abrahamse, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780642/
https://www.ncbi.nlm.nih.gov/pubmed/35057107
http://dx.doi.org/10.3390/pharmaceutics14010211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780642/
https://www.ncbi.nlm.nih.gov/pubmed/35057107
http://dx.doi.org/10.3390/pharmaceutics14010211

Ejemplares similares