Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development

The main aim of this work is the biopharmaceutical characterization of a new hybrid benzodiazepine-dihydropyridine derivative, JM-20, derived with potent anti-ischemic and neuroprotective effects. In this study, the pKa and the pH-solubility profile were experimentally determined. Additionally, effe...

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Detalles Bibliográficos
Autores principales: Miranda, Claudia, Ruiz-Picazo, Alejandro, Pomares, Paula, Gonzalez-Alvarez, Isabel, Bermejo, Marival, Gonzalez-Alvarez, Marta, Avdeef, Alex, Cabrera-Pérez, Miguel-Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780741/
https://www.ncbi.nlm.nih.gov/pubmed/35057075
http://dx.doi.org/10.3390/pharmaceutics14010182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780741/
https://www.ncbi.nlm.nih.gov/pubmed/35057075
http://dx.doi.org/10.3390/pharmaceutics14010182

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