Safe and Effective Cynomolgus Monkey GLP—Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders

The capability of the adult central nervous system to self-repair/regenerate was demonstrated repeatedly throughout the last decades but remains in debate. Reduced neurogenic niche activity paralleled by a profound neuronal loss represents fundamental hallmarks in the disease course of neurodegenera...

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Detalles Bibliográficos
Autores principales: Peters, Sebastian, Wirkert, Eva, Kuespert, Sabrina, Heydn, Rosmarie, Johannesen, Siw, Friedrich, Anita, Mailänder, Susanne, Korte, Sven, Mecklenburg, Lars, Aigner, Ludwig, Bruun, Tim-Henrik, Bogdahn, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780845/
https://www.ncbi.nlm.nih.gov/pubmed/35057094
http://dx.doi.org/10.3390/pharmaceutics14010200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780845/
https://www.ncbi.nlm.nih.gov/pubmed/35057094
http://dx.doi.org/10.3390/pharmaceutics14010200

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