Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF‐1α/SLC7A11 pathway

OBJECTIVES: Evidences demonstrate that sorafenib alleviates liver fibrosis via inhibiting HSC activation and ECM accumulation. The underlying mechanism remains unclear. Ferroptosis, a novel programmed cell death, regulates diverse physiological/pathological processes. In this study, we aim to invest...

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Detalles Bibliográficos
Autores principales: Yuan, Siyu, Wei, Can, Liu, Guofang, Zhang, Lijun, Li, Jiahao, Li, Lingling, Cai, Shiyi, Fang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780895/
https://www.ncbi.nlm.nih.gov/pubmed/34811833
http://dx.doi.org/10.1111/cpr.13158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780895/
https://www.ncbi.nlm.nih.gov/pubmed/34811833
http://dx.doi.org/10.1111/cpr.13158

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