NACA and LRP6 Are Part of a Common Genetic Pathway Necessary for Full Anabolic Response to Intermittent PTH

PTH induces phosphorylation of the transcriptional coregulator NACA on serine 99 through Gαs and PKA. This leads to nuclear translocation of NACA and expression of the target gene Lrp6, encoding a coreceptor of the PTH receptor (PTH1R) necessary for full anabolic response to intermittent PTH (iPTH)...

Descripción completa

Detalles Bibliográficos
Autores principales: St-Arnaud, René, Pellicelli, Martin, Ismail, Mahmoud, Arabian, Alice, Jafarov, Toghrul, Zhou, Chengji J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780913/
https://www.ncbi.nlm.nih.gov/pubmed/35055125
http://dx.doi.org/10.3390/ijms23020940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780913/
https://www.ncbi.nlm.nih.gov/pubmed/35055125
http://dx.doi.org/10.3390/ijms23020940

Ejemplares similares