In Silico Prediction and Validation of CB2 Allosteric Binding Sites to Aid the Design of Allosteric Modulators

Although the 3D structures of active and inactive cannabinoid receptors type 2 (CB2) are available, neither the X-ray crystal nor the cryo-EM structure of CB2-orthosteric ligand-modulator has been resolved, prohibiting the drug discovery and development of CB2 allosteric modulators (AMs). In the pre...

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Detalles Bibliográficos
Autores principales: Yuan, Jiayi, Jiang, Chen, Wang, Junmei, Chen, Chih-Jung, Hao, Yixuan, Zhao, Guangyi, Feng, Zhiwei, Xie, Xiang-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781014/
https://www.ncbi.nlm.nih.gov/pubmed/35056767
http://dx.doi.org/10.3390/molecules27020453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781014/
https://www.ncbi.nlm.nih.gov/pubmed/35056767
http://dx.doi.org/10.3390/molecules27020453

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