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Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids
The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-quadruplexes can be suitable drug targets and many small molecules have been identified to date as G-quadruplex binders, some using computer-based design methods and co-crystal structures. The role of bound wate...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781208/ https://www.ncbi.nlm.nih.gov/pubmed/35056064 http://dx.doi.org/10.3390/ph15010007 |