Two Novel Palbociclib-Resorcinol and Palbociclib-Orcinol Cocrystals with Enhanced Solubility and Dissolution Rate

Palbociclib (PAL) is an effective anti-breast cancer drug, but its use has been partly restricted due to poor bioavailability (resulting from extremely low water solubility) and serious adverse reactions. In this study, two cocrystals of PAL with resorcinol (RES) or orcinol (ORC) were prepared by ev...

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Detalles Bibliográficos
Autores principales: Duan, Chenxin, Liu, Wenwen, Tao, Yunwen, Liang, Feifei, Chen, Yanming, Xiao, Xinyi, Zhang, Guisen, Chen, Yin, Hao, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781472/
https://www.ncbi.nlm.nih.gov/pubmed/35056919
http://dx.doi.org/10.3390/pharmaceutics14010023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781472/
https://www.ncbi.nlm.nih.gov/pubmed/35056919
http://dx.doi.org/10.3390/pharmaceutics14010023

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