Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors †

The design of novel nucleoside triphosphate (NTP) analogues bearing an all-carbon quaternary center at C2′ or C3′ is described. The construction of this all-carbon stereogenic center involves the use of an intramoleculer photoredox-catalyzed reaction. The nucleoside analogues (NA) hydroxyl functiona...

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Detalles Bibliográficos
Autores principales: Manchoju, Amarender, Zelli, Renaud, Wang, Gang, Eymard, Carla, Oo, Adrian, Nemer, Mona, Prévost, Michel, Kim, Baek, Guindon, Yvan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781509/
https://www.ncbi.nlm.nih.gov/pubmed/35056878
http://dx.doi.org/10.3390/molecules27020564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781509/
https://www.ncbi.nlm.nih.gov/pubmed/35056878
http://dx.doi.org/10.3390/molecules27020564

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