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Lipid Membrane State Change by Catalytic Protonation and the Implications for Synaptic Transmission

In cholinergic synapses, the neurotransmitter acetylcholine (ACh) is rapidly hydrolyzed by esterases to choline and acetic acid (AH). It is believed that this reaction serves the purpose of deactivating ACh once it has exerted its effect on a receptor protein (AChR). The protons liberated in this re...

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Detalles Bibliográficos
Autores principales: Fillafer, Christian, Koll, Yana S., Schneider, Matthias F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781637/
https://www.ncbi.nlm.nih.gov/pubmed/35054529
http://dx.doi.org/10.3390/membranes12010005