Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway

Ursodeoxycholic acid (UDCA) is a first-line clinical drug for the treatment of liver diseases. U12, a derivative of UDCA, showed effective anti-hepatoma activities in previous works. However, the low polarity and large doses limited the druglikeness of U12. In this study, the structural modification...

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Detalles Bibliográficos
Autores principales: Yang, Renjing, Du, Chunchun, Cao, Ting, Wang, Guanghui, Jiang, Xin, Gao, Jun, Lin, Ting, Sun, Cuiling, Ding, Rong, Tian, Wenjing, Chen, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781819/
https://www.ncbi.nlm.nih.gov/pubmed/35056164
http://dx.doi.org/10.3390/ph15010107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781819/
https://www.ncbi.nlm.nih.gov/pubmed/35056164
http://dx.doi.org/10.3390/ph15010107

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