Structural Basis of 2-Phenylamino-4-phenoxyquinoline Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

New target molecules, namely, 2-phenylamino-4-phenoxyquinoline derivatives, were designed using a molecular hybridization approach, which was accomplished by fusing the pharmacophore structures of three currently available drugs: nevirapine, efavirenz, and rilpivirine. The discovery of disubstituted...

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Detalles Bibliográficos
Autores principales: Makarasen, Arthit, Patnin, Suwicha, Vijitphan, Pongsit, Reukngam, Nanthawan, Khlaychan, Panita, Kuno, Mayuso, Intachote, Pakamas, Saimanee, Busakorn, Sengsai, Suchada, Techasakul, Supanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781960/
https://www.ncbi.nlm.nih.gov/pubmed/35056776
http://dx.doi.org/10.3390/molecules27020461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781960/
https://www.ncbi.nlm.nih.gov/pubmed/35056776
http://dx.doi.org/10.3390/molecules27020461

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