Cargando…

The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila

Statins, HMG Coenzyme A Reductase (HMGCR) inhibitors, are a first-line therapy, used to reduce hypercholesterolemia and the risk for cardiovascular events. While sleep disturbances are recognized as a side-effect of statin treatment, the impact of statins on sleep is under debate. Using Drosophila,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alsehli, Ahmed M., Liao, Sifang, Al-Sabri, Mohamed H., Vasionis, Lukas, Purohit, Archana, Behare, Neha, Clemensson, Laura E., Williams, Michael J., Schiöth, Helgi B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781969/ https://www.ncbi.nlm.nih.gov/pubmed/35056136 http://dx.doi.org/10.3390/ph15010079

Ejemplares similares

The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms
por: Williams, Michael J., et al.
Publicado: (2022)

The Cognitive Effects of Statins are Modified by Age
por: Alsehli, Ahmed M., et al.
Publicado: (2020)

Statin-Induced Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (Anti-HMGCR) Myopathy
por: Ghazal, Fatima, et al.
Publicado: (2023)

Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes
por: Al-Sabri, Mohamed H., et al.
Publicado: (2022)

The Effects of Statins on Cognitive Performance Are Mediated by Low-Density Lipoprotein, C-Reactive Protein, and Blood Glucose Concentrations
por: Gentreau, Mélissa, et al.
Publicado: (2023)

Statins and cognition: Modifying factors and possible underlying mechanisms
por: Jamshidnejad-Tosaramandani, Tahereh, et al.
Publicado: (2022)

A Possible Role for HMG-CoA Reductase Inhibitors and Its Association with HMGCR Genetic Variation in Parkinson’s Disease
por: Pierzchlińska, Anna, et al.
Publicado: (2021)

The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases
por: Friesen, Jon A, et al.
Publicado: (2004)

Selection of HMG-coenzyme A reductase inhibitors using multiattribute scoring tool
por: Ramli, Azuana, et al.
Publicado: (2012)

HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis
por: Zhong, Zhenyu, et al.
Publicado: (2021)

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase
por: Würtz, Peter, et al.
Publicado: (2016)

Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor
por: Bose, Sucharita, et al.
Publicado: (2023)

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
por: Jiang, Shi-You, et al.
Publicado: (2018)

HMG CoA reductase inhibitors (statins) to treat Epstein–Barr virus-driven lymphoma
por: Cohen, J I
Publicado: (2005)

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis
por: Palmer, Suetonia C., et al.
Publicado: (2015)

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis
por: Palmer, Suetonia C., et al.
Publicado: (2014)

Chronic Anti-HMG-CoA Reductase Positive Necrotizing Myositis With Remote Exposure to Statins
por: Salar, Tooba, et al.
Publicado: (2023)

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
por: Swerdlow, Daniel I, et al.
Publicado: (2015)

Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers
por: Meisel, Peter, et al.
Publicado: (2011)

Benefit–risk assessment of HMG-CoA reductase inhibitors (statins): a discrete choice experiment
por: Wanishayakorn, Tanatape, et al.
Publicado: (2016)

Statins: HMG-CoA Reductase Inhibitors as Potential Anticancer Agents against Malignant Neoplasms in Women
por: Markowska, Anna, et al.
Publicado: (2020)

A Mendelian Randomization Approach Using 3-HMG-Coenzyme-A Reductase Gene Variation to Evaluate the Association of Statin-Induced Low-Density Lipoprotein Cholesterol Lowering With Noncardiovascular Disease Phenotypes
por: Liu, Ge, et al.
Publicado: (2021)

Predictive Modeling of HMG-CoA Reductase Inhibitory Activity and Design of New HMG-CoA Reductase Inhibitors
por: Samizo, Shigeyoshi, et al.
Publicado: (2023)

The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase
por: Maciejak, Agata, et al.
Publicado: (2013)

Anti-HMG-CoA reductase myopathy, an undesirable evolution of statin induced myopathy: a case report
por: Upreti, Sunita, et al.
Publicado: (2019)

HMG-CoA Reductase Inhibitor Statins Activate the Transcriptional Activity of p53 by Regulating the Expression of TAZ
por: Miyajima, Chiharu, et al.
Publicado: (2022)

Anti-HMGCR Myopathy without Exposure to Statins: A Case Report
por: Ferriz Vivancos, Jorge, et al.
Publicado: (2022)

A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus
por: Stormo, Camilla, et al.
Publicado: (2012)

Low Density Lipoprotein Receptor (LDLR) and 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase (HMGCR) Expression are Associated with Platinum-Resistance and Prognosis in Ovarian Carcinoma Patients
por: Huang, Xueyao, et al.
Publicado: (2021)

Can HMG Co-A reductase inhibitors (“statins”) slow the progression of age-related macular degeneration? The Age-Related Maculopathy Statin Study (ARMSS)
por: Guymer, Robyn H, et al.
Publicado: (2008)

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?
por: Gonzalez-Jimenez, Irene, et al.
Publicado: (2021)

7-Acetoxyhorminone from Salvia multicaulis Vahl. as Promising Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase
por: Yigitkan, Serkan, et al.
Publicado: (2022)

Anti-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (Anti-HMG CoA) Myopathy With Cardiac Involvement: Presentation, Diagnosis, and Management
por: Liu, Lisa, et al.
Publicado: (2022)

Pleiotropic effects of the HMG-CoA reductase inhibitors
por: Mihos, Christos G, et al.
Publicado: (2011)

Proposed cut-off for reactivity of anti-HMGCR and anti-SRP antibodies in patients statin-exposed and statin-unexposed
por: Carvalho, Alzira Alves Siqueira, et al.
Publicado: (2018)

HMG-CoA reductase inhibitors in kidney transplant recipients receiving tacrolimus: statins not associated with improved patient or graft survival
por: Younas, Nizar, et al.
Publicado: (2010)

AB126. Impact of HMG-CoA reductase inhibitor (statin) use on serum PSA and prostate volume in BPH patients
por: Park, Heung Jae
Publicado: (2014)

Statins, HMG-CoA Reductase Inhibitors, Improve Neovascularization by Increasing the Expression Density of CXCR4 in Endothelial Progenitor Cells
por: Chiang, Kuang-Hsing, et al.
Publicado: (2015)

Model Lipid Raft Membranes for Embedding Integral Membrane Proteins: Reconstitution of HMG-CoA Reductase and Its Inhibition by Statins
por: Zaborowska, Michalina, et al.
Publicado: (2022)

Anti-HMGCR Autoantibodies in European Patients With Autoimmune Necrotizing Myopathies: Inconstant Exposure to Statin
por: Allenbach, Yves, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_lhmu4rsqmlef4m9q60054u88jh