A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro

The Alzheimer’s brain is affected by multiple pathophysiological processes, which include a unique, organ-specific form of insulin resistance that begins early in its course. An additional complexity arises from the four-fold risk of Alzheimer’s Disease (AD) in type 2 diabetics, however there is no...

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Detalles Bibliográficos
Autores principales: Querfurth, Henry, Marshall, John, Parang, Keykavous, Rioult-Pedotti, Mengia S., Tiwari, Rakesh, Kwon, Bumsup, Reisinger, Steve, Lee, Han-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782417/
https://www.ncbi.nlm.nih.gov/pubmed/35061720
http://dx.doi.org/10.1371/journal.pone.0261696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782417/
https://www.ncbi.nlm.nih.gov/pubmed/35061720
http://dx.doi.org/10.1371/journal.pone.0261696

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