Enzymatic transfer of acetate on histones from lysine reservoir sites to lysine activating sites

Histone acetylation is governed by nuclear acetyl-CoA pools generated, in part, from local acetate by metabolic enzyme acetyl-CoA synthetase 2 (ACSS2). We hypothesize that during gene activation, a local transfer of intact acetate occurs via sequential action of epigenetic and metabolic enzymes. Usi...

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Detalles Bibliográficos
Autores principales: Mendoza, Mariel, Egervari, Gabor, Sidoli, Simone, Donahue, Greg, Alexander, Desi C., Sen, Payel, Garcia, Benjamin A., Berger, Shelley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782443/
https://www.ncbi.nlm.nih.gov/pubmed/35061542
http://dx.doi.org/10.1126/sciadv.abj5688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782443/
https://www.ncbi.nlm.nih.gov/pubmed/35061542
http://dx.doi.org/10.1126/sciadv.abj5688

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