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Enzymatic transfer of acetate on histones from lysine reservoir sites to lysine activating sites
Histone acetylation is governed by nuclear acetyl-CoA pools generated, in part, from local acetate by metabolic enzyme acetyl-CoA synthetase 2 (ACSS2). We hypothesize that during gene activation, a local transfer of intact acetate occurs via sequential action of epigenetic and metabolic enzymes. Usi...
Autores principales: | Mendoza, Mariel, Egervari, Gabor, Sidoli, Simone, Donahue, Greg, Alexander, Desi C., Sen, Payel, Garcia, Benjamin A., Berger, Shelley L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782443/ https://www.ncbi.nlm.nih.gov/pubmed/35061542 http://dx.doi.org/10.1126/sciadv.abj5688 |
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