Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins

Human cytomegalovirus (HCMV) encodes G protein–coupled receptors (GPCRs) US28 and US27, which facilitate viral pathogenesis through engagement of host G proteins. Here we report cryo–electron microscopy structures of US28 and US27 forming nonproductive and productive complexes with Gi and Gq, respec...

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Detalles Bibliográficos
Autores principales: Tsutsumi, Naotaka, Maeda, Shoji, Qu, Qianhui, Vögele, Martin, Jude, Kevin M., Suomivuori, Carl-Mikael, Panova, Ouliana, Waghray, Deepa, Kato, Hideaki E., Velasco, Andrew, Dror, Ron O., Skiniotis, Georgios, Kobilka, Brian K., Garcia, K. Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782444/
https://www.ncbi.nlm.nih.gov/pubmed/35061538
http://dx.doi.org/10.1126/sciadv.abl5442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782444/
https://www.ncbi.nlm.nih.gov/pubmed/35061538
http://dx.doi.org/10.1126/sciadv.abl5442

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