SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia

The production of noncanonical mRNA transcripts is associated with cell transformation. Driven by our previous findings on the sensitivity of T cell acute lymphoblastic leukemia (T-ALL) cells to SF3B1 inhibitors, we identified that SF3B1 inhibition blocks T-ALL growth in vivo with no notable associa...

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Detalles Bibliográficos
Autores principales: Han, Cuijuan, Khodadadi-Jamayran, Alireza, Lorch, Adam H., Jin, Qi, Serafin, Valentina, Zhu, Ping, Politanska, Yuliya, Sun, Limin, Gutierrez-Diaz, Blanca T., Pryzhkova, Marina V., Abdala-Valencia, Hiam, Bartom, Elizabeth Thomas, Buldini, Barbara, Basso, Giuseppe, Velu, Sadanandan E., Sarma, Kavitha, Mattamana, Basil B., Cho, Byoung-Kyu, Obeng, Rebecca C., Goo, Young Ah, Jordan, Philip W., Tsirigos, Aristotelis, Zhou, Yalu, Ntziachristos, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782448/
https://www.ncbi.nlm.nih.gov/pubmed/35061527
http://dx.doi.org/10.1126/sciadv.abj8357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782448/
https://www.ncbi.nlm.nih.gov/pubmed/35061527
http://dx.doi.org/10.1126/sciadv.abj8357

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