Cargando…

SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia

The production of noncanonical mRNA transcripts is associated with cell transformation. Driven by our previous findings on the sensitivity of T cell acute lymphoblastic leukemia (T-ALL) cells to SF3B1 inhibitors, we identified that SF3B1 inhibition blocks T-ALL growth in vivo with no notable associa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Cuijuan, Khodadadi-Jamayran, Alireza, Lorch, Adam H., Jin, Qi, Serafin, Valentina, Zhu, Ping, Politanska, Yuliya, Sun, Limin, Gutierrez-Diaz, Blanca T., Pryzhkova, Marina V., Abdala-Valencia, Hiam, Bartom, Elizabeth Thomas, Buldini, Barbara, Basso, Giuseppe, Velu, Sadanandan E., Sarma, Kavitha, Mattamana, Basil B., Cho, Byoung-Kyu, Obeng, Rebecca C., Goo, Young Ah, Jordan, Philip W., Tsirigos, Aristotelis, Zhou, Yalu, Ntziachristos, Panagiotis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782448/ https://www.ncbi.nlm.nih.gov/pubmed/35061527 http://dx.doi.org/10.1126/sciadv.abj8357

Ejemplares similares

Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia
por: Jin, Qi, et al.
Publicado: (2022)

Expression of ACE2—a Key SARS-CoV-2 Entry Factor—Is Not Increased in the Nasal Mucosa of People with Cystic Fibrosis
por: Sala, Marc A., et al.
Publicado: (2022)

Decreased cytotoxic T cells and TCR clonality in organ transplant recipients with squamous cell carcinoma
por: Frazzette, Nicholas, et al.
Publicado: (2020)

The Transcription Factor Zfx Regulates Peripheral T Cell Self-Renewal and Proliferation
por: Smith-Raska, Matthew R., et al.
Publicado: (2018)

Apolipoprotein E4 Effects a Distinct Transcriptomic Profile and Dendritic Arbor Characteristics in Hippocampal Neurons Cultured in vitro
por: Diaz, Jenny R., et al.
Publicado: (2022)

High-resolution cryo-EM structure of the Shigella virus Sf6 genome delivery tail machine
por: Li, Fenglin, et al.
Publicado: (2022)

ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes
por: Shekhar, Akshay, et al.
Publicado: (2018)

Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non–small cell lung cancer
por: Huang, Qingyuan, et al.
Publicado: (2022)

HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking
por: Lazaris, Charalampos, et al.
Publicado: (2017)

Expression of vimentin alters cell mechanics, cell-cell adhesion, and gene expression profiles suggesting the induction of a hybrid EMT in human mammary epithelial cells
por: Sivagurunathan, Suganya, et al.
Publicado: (2022)

KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer
por: Xiong, Xiaozhong, et al.
Publicado: (2018)

Aging imparts cell-autonomous dysfunction to regulatory T cells during recovery from influenza pneumonia
por: Morales-Nebreda, Luisa, et al.
Publicado: (2021)

Cilia-related gene signature in the nasal mucosa correlates with disease severity and outcomes in critical respiratory syncytial virus bronchiolitis
por: Koch, Clarissa M., et al.
Publicado: (2022)

The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis
por: Moubarak, Rana S., et al.
Publicado: (2022)

Development of a large-scale isolation chamber system for the safe and humane care of medium-sized laboratory animals harboring infectious diseases
por: Pan, Xin, et al.
Publicado: (2010)

Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations
por: Zhu, Bo-feng, et al.
Publicado: (2010)

Sporadic Creutzfeldt–Jakob disease subtype-specific alterations of the brain proteome: Impact on Rab3a recycling
por: Gawinecka, Joanna, et al.
Publicado: (2012)

Surface modifications of influenza proteins upon virus inactivation by β-propiolactone*
por: She, Yi-Min, et al.
Publicado: (2013)

Applications of mass spectrometry for quantitative protein analysis in formalin-fixed paraffin-embedded tissues
por: Steiner, Carine, et al.
Publicado: (2014)

MALDI Mass Spectrometry Imaging: A Novel Tool for the Identification and Classification of Amyloidosis
por: Winter, Martin, et al.
Publicado: (2017)

Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care
por: Chung, Ha Uk, et al.
Publicado: (2019)

Proteomics insights into DNA damage response and translating this knowledge to clinical strategies
por: von Stechow, Louise, et al.
Publicado: (2016)

Proteomic characterization of microdissected breast tissue environment provides a protein‐level overview of malignant transformation
por: Braakman, René B. H., et al.
Publicado: (2017)

Prognostic role of elevated mir-24-3p in breast cancer and its association with the metastatic process
por: Khodadadi-Jamayran, Alireza, et al.
Publicado: (2018)

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells
por: Kirkling, Margaret E., et al.
Publicado: (2018)

LncRNA RP11-19E11 is an E2F1 target required for proliferation and survival of basal breast cancer
por: Giro-Perafita, A., et al.
Publicado: (2020)

Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries
por: Gong, Yixiao, et al.
Publicado: (2018)

PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer
por: Zhao, Zibo, et al.
Publicado: (2021)

Lung transplantation for patients with severe COVID-19
por: Bharat, Ankit, et al.
Publicado: (2020)

Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells
por: Yang, Zhenhua, et al.
Publicado: (2016)

Control of Hematopoietic Stem and Progenitor Cell Function through Epigenetic Regulation of Energy Metabolism and Genome Integrity
por: Yang, Zhenhua, et al.
Publicado: (2019)

Spatial interplay patterns of cancer nuclei and tumor-infiltrating lymphocytes (TILs) predict clinical benefit for immune checkpoint inhibitors
por: Wang, Xiangxue, et al.
Publicado: (2022)

Host nucleases generate prespacers for primed adaptation in the E. coli type I-E CRISPR-Cas system
por: Shiriaeva, Anna A., et al.
Publicado: (2022)

Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth
por: Sharma, Abhineet M., et al.
Publicado: (2022)

ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection
por: Ching, Krystal L., et al.
Publicado: (2022)

Single-cell RNA sequencing reveals distinct T cell populations in immune-related adverse events of checkpoint inhibitors
por: Bukhari, Shoiab, et al.
Publicado: (2022)

Human and mouse introns are linked to the same processes and functions through each genome's most frequent non-conserved motifs
por: Tsirigos, Aristotelis, et al.
Publicado: (2008)

A sensitive, support-vector-machine method for the detection of horizontal gene transfers in viral, archaeal and bacterial genomes
por: Tsirigos, Aristotelis, et al.
Publicado: (2005)

A new computational method for the detection of horizontal gene transfer events
por: Tsirigos, Aristotelis, et al.
Publicado: (2005)

Alu and B1 Repeats Have Been Selectively Retained in the Upstream and Intronic Regions of Genes of Specific Functional Classes
por: Tsirigos, Aristotelis, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_u75c7sh966nliufop71mrj3982