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Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance
Chondrocytes secrete massive extracellular matrix (ECM) molecules that are produced, folded, and modified in the endoplasmic reticulum (ER). Thus, the ER-associated degradation (ERAD) complex—which removes misfolded and unfolded proteins to maintain proteostasis in the ER— plays an indispensable rol...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782459/ https://www.ncbi.nlm.nih.gov/pubmed/35061535 http://dx.doi.org/10.1126/sciadv.abl4222 |