Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance

Chondrocytes secrete massive extracellular matrix (ECM) molecules that are produced, folded, and modified in the endoplasmic reticulum (ER). Thus, the ER-associated degradation (ERAD) complex—which removes misfolded and unfolded proteins to maintain proteostasis in the ER— plays an indispensable rol...

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Detalles Bibliográficos
Autores principales: Sim, Hyo Jung, Cho, Chanmi, Kim, Ha Eun, Hong, Ju Yeon, Song, Eun Kyung, Kwon, Keun Yeong, Jang, Dong Gil, Kim, Seok-Jung, Lee, Hyun-Shik, Lee, Changwook, Kwon, Taejoon, Yang, Siyoung, Park, Tae Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782459/
https://www.ncbi.nlm.nih.gov/pubmed/35061535
http://dx.doi.org/10.1126/sciadv.abl4222

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