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Linking protein structural and functional change to mutation using amino acid networks

The function of a protein is strongly dependent on its structure. During evolution, proteins acquire new functions through mutations in the amino-acid sequence. Given the advance in deep mutational scanning, recent findings have found functional change to be position dependent, notwithstanding the c...

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Detalles Bibliográficos
Autores principales: Sotomayor-Vivas, Cristina, Hernández-Lemus, Enrique, Dorantes-Gilardi, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782487/
https://www.ncbi.nlm.nih.gov/pubmed/35061689
http://dx.doi.org/10.1371/journal.pone.0261829