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Linking protein structural and functional change to mutation using amino acid networks
The function of a protein is strongly dependent on its structure. During evolution, proteins acquire new functions through mutations in the amino-acid sequence. Given the advance in deep mutational scanning, recent findings have found functional change to be position dependent, notwithstanding the c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782487/ https://www.ncbi.nlm.nih.gov/pubmed/35061689 http://dx.doi.org/10.1371/journal.pone.0261829 |