Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo

Cathepsin K is highly expressed in various types of cancers. However, the effect of cathepsin K inhibition in cancer cells is not well characterized. Here, cathepsin K inhibitor (odanacatib; ODN) and knockdown of cathepsin K (siRNA) enhanced oxaliplatin-induced apoptosis in multiple cancer cells thr...

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Detalles Bibliográficos
Autores principales: Seo, Seung Un, Woo, Seon Min, Kim, Shin, Park, Jong-Wook, Lee, Hyun-Shik, Bae, Young-Seuk, Kim, Sang Hyun, Im, Seung-Soon, Seo, Ji Hae, Min, Kyoung-jin, Kwon, Taeg Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782718/
https://www.ncbi.nlm.nih.gov/pubmed/34785775
http://dx.doi.org/10.1038/s41388-021-02088-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782718/
https://www.ncbi.nlm.nih.gov/pubmed/34785775
http://dx.doi.org/10.1038/s41388-021-02088-7

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