Cargando…

Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo

Cathepsin K is highly expressed in various types of cancers. However, the effect of cathepsin K inhibition in cancer cells is not well characterized. Here, cathepsin K inhibitor (odanacatib; ODN) and knockdown of cathepsin K (siRNA) enhanced oxaliplatin-induced apoptosis in multiple cancer cells thr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seo, Seung Un, Woo, Seon Min, Kim, Shin, Park, Jong-Wook, Lee, Hyun-Shik, Bae, Young-Seuk, Kim, Sang Hyun, Im, Seung-Soon, Seo, Ji Hae, Min, Kyoung-jin, Kwon, Taeg Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782718/ https://www.ncbi.nlm.nih.gov/pubmed/34785775 http://dx.doi.org/10.1038/s41388-021-02088-7

Ejemplares similares

Cathepsin K inhibition induces Raptor destabilization and mitochondrial dysfunction via Syk/SHP2/Src/OTUB1 axis-mediated signaling
por: Seo, Seung Un, et al.
Publicado: (2023)

BAP1 phosphorylation-mediated Sp1 stabilization plays a critical role in cathepsin K inhibition-induced C-terminal p53-dependent Bax upregulation
por: Seo, Seung Un, et al.
Publicado: (2022)

Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress
por: Seo, Seung Un, et al.
Publicado: (2018)

Cathepsin D as a potential therapeutic target to enhance anticancer drug-induced apoptosis via RNF183-mediated destabilization of Bcl-xL in cancer cells
por: Seo, Seung Un, et al.
Publicado: (2022)

Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin
por: Woo, Seon Min, et al.
Publicado: (2017)

Cathepsin K inhibition-induced mitochondrial ROS enhances sensitivity of cancer cells to anti-cancer drugs through USP27x-mediated Bim protein stabilization
por: Seo, Seung Un, et al.
Publicado: (2019)

Itch and autophagy-mediated NF-κB activation contributes to inhibition of cathepsin D-induced sensitizing effect on anticancer drugs
por: Seo, Seung Un, et al.
Publicado: (2022)

OTUB1 knockdown promotes apoptosis in melanoma cells by upregulating TRAIL expression
por: Lee, Bok-Soon, et al.
Publicado: (2021)

mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy
por: Seo, Seung Un, et al.
Publicado: (2018)

Corosolic Acid Induces Non-Apoptotic Cell Death through Generation of Lipid Reactive Oxygen Species Production in Human Renal Carcinoma Caki Cells
por: Woo, Seon Min, et al.
Publicado: (2018)

Lucanthone, Autophagy Inhibitor, Enhances the Apoptotic Effects of TRAIL through miR-216a-5p-Mediated DR5 Upregulation and DUB3-Mediated Mcl-1 Downregulation
por: Yoon, Ji Yun, et al.
Publicado: (2021)

BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression
por: Woo, Seon Min, et al.
Publicado: (2018)

Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation
por: Song, So Rae, et al.
Publicado: (2023)

HSP70 Acetylation Prevents Combined mTORC1/2 Inhibitor and Curcumin Treatment-Induced Apoptosis
por: Seo, Seung Un, et al.
Publicado: (2018)

Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation
por: Yoo, Ki-Chun, et al.
Publicado: (2012)

NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin
por: Seo, Seung Un, et al.
Publicado: (2017)

Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
por: Kim, Seok, et al.
Publicado: (2018)

Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP
por: Jeon, Mi-Yeon, et al.
Publicado: (2018)

Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells
por: Jeon, Mi-Yeon, et al.
Publicado: (2020)

Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5
por: Woo, Seon Min, et al.
Publicado: (2022)

Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization
por: Wu, Kaixin, et al.
Publicado: (2021)

Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway
por: Shahriyar, Sk Abrar, et al.
Publicado: (2020)

USP41 Enhances Epithelial–Mesenchymal Transition of Breast Cancer Cells through Snail Stabilization
por: Yoon, Ji-Yun, et al.
Publicado: (2023)

Hispidulin Enhances TRAIL-Mediated Apoptosis via CaMKKβ/AMPK/USP51 Axis-Mediated Bim Stabilization
por: Woo, Seon Min, et al.
Publicado: (2019)

Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells
por: Han, Min Ae, et al.
Publicado: (2016)

Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation
por: Woo, Seon Min, et al.
Publicado: (2019)

Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells
por: Yun, Jeong Mi, et al.
Publicado: (2018)

Cepharanthine Enhances TRAIL-Mediated Apoptosis Through STAMBPL1-Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells
por: Shahriyar, Sk Abrar, et al.
Publicado: (2018)

Eupafolin enhances TRAIL-mediated apoptosis through cathepsin S-induced down-regulation of Mcl-1 expression and AMPK-mediated Bim up-regulation in renal carcinoma Caki cells
por: Han, Min Ae, et al.
Publicado: (2016)

YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-κB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells
por: Woo, Seon Min, et al.
Publicado: (2016)

Allosteric Sensitization of Pro-Apoptotic BAX
por: Pritz, Jonathan R., et al.
Publicado: (2017)

Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma
por: Woo, Seon Min, et al.
Publicado: (2019)

Volasertib Enhances Sensitivity to TRAIL in Renal Carcinoma Caki Cells through Downregulation of c-FLIP Expression
por: Jeon, Mi-Yeon, et al.
Publicado: (2017)

Expression of Ca(2+)-dependent Synaptotagmin Isoforms in Mouse and Rat Parotid Acinar Cells
por: Jo, Hae, et al.
Publicado: (2006)

A Prospective Study of Chronic Oxaliplatin-Induced Neuropathy in Patients with Colon Cancer: Long-Term Outcomes and Predictors of Severe Oxaliplatin-Induced Neuropathy
por: Kim, Su-Hyun, et al.
Publicado: (2018)

WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP
por: Kim, Seok, et al.
Publicado: (2019)

The mechanism of OTUB1 inhibition of ubiquitination
por: Wiener, Reuven, et al.
Publicado: (2012)

Inhibition of USP2 Enhances TRAIL-Mediated Cancer Cell Death through Downregulation of Survivin
por: Lee, Tak Gyeom, et al.
Publicado: (2023)

Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis
por: Soond, Surinder M., et al.
Publicado: (2021)

Bioactive lipids and the control of Bax pro-apoptotic activity
por: Mignard, V, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vqlicrqmssimah1o3ef84bupru