Emergence of β1 integrin-deficient breast tumours from dormancy involves both inactivation of p53 and generation of a permissive tumour microenvironment

The molecular and cellular mechanisms underlying mammary tumour dormancy and cancer recurrence are unclear and remain to be elucidated. Here, we report that mammary epithelial-specific disruption of β1 integrin in a murine model of Luminal B human breast cancer drastically impairs tumour growth with...

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Detalles Bibliográficos
Autores principales: Bui, Tung, Gu, Yu, Ancot, Frédéric, Sanguin-Gendreau, Virginie, Zuo, Dongmei, Muller, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782722/
https://www.ncbi.nlm.nih.gov/pubmed/34782719
http://dx.doi.org/10.1038/s41388-021-02107-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782722/
https://www.ncbi.nlm.nih.gov/pubmed/34782719
http://dx.doi.org/10.1038/s41388-021-02107-7

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