CHK1 inhibition exacerbates replication stress induced by IGF blockade

We recently reported that genetic or pharmacological inhibition of insulin-like growth factor receptor (IGF-1R) slows DNA replication and induces replication stress by downregulating the regulatory subunit RRM2 of ribonucleotide reductase, perturbing deoxynucleotide triphosphate (dNTP) supply. Aimin...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xiaoning, Seraia, Elena, Hatch, Stephanie B., Wan, Xiao, Ebner, Daniel V., Aroldi, Francesca, Jiang, Yanyan, Ryan, Anderson J., Bogenrieder, Thomas, Weyer-Czernilofsky, Ulrike, Rieunier, Guillaume, Macaulay, Valentine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782724/
https://www.ncbi.nlm.nih.gov/pubmed/34773074
http://dx.doi.org/10.1038/s41388-021-02080-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782724/
https://www.ncbi.nlm.nih.gov/pubmed/34773074
http://dx.doi.org/10.1038/s41388-021-02080-1

Ejemplares similares