Cargando…

CHK1 inhibition exacerbates replication stress induced by IGF blockade

We recently reported that genetic or pharmacological inhibition of insulin-like growth factor receptor (IGF-1R) slows DNA replication and induces replication stress by downregulating the regulatory subunit RRM2 of ribonucleotide reductase, perturbing deoxynucleotide triphosphate (dNTP) supply. Aimin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Xiaoning, Seraia, Elena, Hatch, Stephanie B., Wan, Xiao, Ebner, Daniel V., Aroldi, Francesca, Jiang, Yanyan, Ryan, Anderson J., Bogenrieder, Thomas, Weyer-Czernilofsky, Ulrike, Rieunier, Guillaume, Macaulay, Valentine M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782724/ https://www.ncbi.nlm.nih.gov/pubmed/34773074 http://dx.doi.org/10.1038/s41388-021-02080-1

Ejemplares similares

Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies
por: Simpson, Aaron, et al.
Publicado: (2017)

Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer
por: Ireland, Lucy, et al.
Publicado: (2018)

IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits
por: Mills, Jack V., et al.
Publicado: (2021)

Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma
por: Simpson, Aaron D., et al.
Publicado: (2019)

Therapeutic Targeting of the IGF Axis
por: Osher, Eliot, et al.
Publicado: (2019)

Targeting Chk1 in the replicative stress response
por: Dai, Yun, et al.
Publicado: (2010)

A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer
por: Macaulay, Valentine M., et al.
Publicado: (2023)

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
por: Feijoo, Carmen, et al.
Publicado: (2001)

CHK1 phosphorylates PRIMPOL to promote replication stress tolerance
por: Mehta, Kavi P. M., et al.
Publicado: (2022)

Chk1, Chk2, is the amplifier on?
por: Dove, Alan W.
Publicado: (2001)

Tight Chk1 Levels Control Replication Cluster Activation in Xenopus
por: Platel, Marie, et al.
Publicado: (2015)

ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress
por: Wu, Xingxuan, et al.
Publicado: (2022)

Wee1 and Chk1 – crosstalk between key players in replicative stress
por: Saini, Priyanka, et al.
Publicado: (2015)

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation
por: López-Contreras, Andres J., et al.
Publicado: (2012)

Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress
por: Saini, Priyanka, et al.
Publicado: (2015)

CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation
por: Elvers, Ingegerd, et al.
Publicado: (2012)

Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy
por: Wu, Xiaoning, et al.
Publicado: (2019)

Regulation of Chk1
por: Tapia-Alveal, Claudia, et al.
Publicado: (2009)

Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry
por: Fasulo, Barbara, et al.
Publicado: (2012)

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories
por: Ge, Xin Quan, et al.
Publicado: (2010)

DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response
por: Lin, Yu-Fen, et al.
Publicado: (2014)

Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma
por: Black, Elizabeth M., et al.
Publicado: (2022)

DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation
por: Bétous, Rémy, et al.
Publicado: (2013)

Division of labor of the replication fork protection complex subunits in sister chromatid cohesion and Chk1 activation
por: Noguchi, Eishi
Publicado: (2011)

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication
por: Moiseeva, Tatiana N., et al.
Publicado: (2019)

CEP131 Abrogates CHK1 Inhibitor-Induced Replication Defects and Is Associated with Unfavorable Outcome in Neuroblastoma
por: Ando, Kiyohiro, et al.
Publicado: (2020)

Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer
por: Gralewska, Patrycja, et al.
Publicado: (2020)

Cdc7 activates replication checkpoint by phosphorylating the Chk1-binding domain of Claspin in human cells
por: Yang, Chi-Chun, et al.
Publicado: (2019)

The deubiquitinating enzyme USP37 enhances CHK1 activity to promote the cellular response to replication stress
por: Stromberg, Benjamin R., et al.
Publicado: (2021)

Regulation, targets and functions of CHK
por: Zhu, Shudong, et al.
Publicado: (2022)

Tumour growth environment modulates Chk1 signalling pathways and Chk1 inhibitor sensitivity
por: Massey, Andrew J.
Publicado: (2016)

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy
por: Manic, Gwenola, et al.
Publicado: (2015)

ATR and Chk1 Suppress a Caspase-3–Dependent Apoptotic Response Following DNA Replication Stress
por: Myers, Katie, et al.
Publicado: (2009)

Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1
por: Gagou, Mary E., et al.
Publicado: (2010)

Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells
por: Zuazua-Villar, Pedro, et al.
Publicado: (2015)

Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress
por: Zhang, Yao, et al.
Publicado: (2016)

Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition
por: Mani, Chinnadurai, et al.
Publicado: (2018)

Clinical and functional significance of CHK1-S, an alternatively spliced isoform of the CHK1 gene, in hepatocellular carcinoma
por: Hu, Guanghui, et al.
Publicado: (2020)

Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation
por: Yu, Xinfang, et al.
Publicado: (2020)

Cell cycle-dependent localization of CHK2 at centrosomes during mitosis
por: Chouinard, Guillaume, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ets095dv7d6buvdp0evjbg0n6m