Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

A reduced removal of dysfunctional mitochondria is common to aging and age-related neurodegenerative pathologies such as Alzheimer’s disease (AD). Strategies for treating such impaired mitophagy would benefit from the identification of mitophagy modulators. Here we report the combined use of unsuper...

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Detalles Bibliográficos
Autores principales: Xie, Chenglong, Zhuang, Xu-Xu, Niu, Zhangming, Ai, Ruixue, Lautrup, Sofie, Zheng, Shuangjia, Jiang, Yinghui, Han, Ruiyu, Gupta, Tanima Sen, Cao, Shuqin, Lagartos-Donate, Maria Jose, Cai, Cui-Zan, Xie, Li-Ming, Caponio, Domenica, Wang, Wen-Wen, Schmauck-Medina, Tomas, Zhang, Jianying, Wang, He-ling, Lou, Guofeng, Xiao, Xianglu, Zheng, Wenhua, Palikaras, Konstantinos, Yang, Guang, Caldwell, Kim A., Caldwell, Guy A., Shen, Han-Ming, Nilsen, Hilde, Lu, Jia-Hong, Fang, Evandro F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782726/
https://www.ncbi.nlm.nih.gov/pubmed/34992270
http://dx.doi.org/10.1038/s41551-021-00819-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782726/
https://www.ncbi.nlm.nih.gov/pubmed/34992270
http://dx.doi.org/10.1038/s41551-021-00819-5

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