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Multicomponent double Mannich alkylamination involving C(sp(2))–H and benzylic C(sp(3))–H bonds

Alkylamines are ubiquitous in pharmaceuticals, materials and agrochemicals. The Mannich reaction is a well-known three-component reaction for preparing alkylamines and has been widely used in academic research and industry. However, the nucleophilic components in this process rely on C(sp(2))−H and...

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Detalles Bibliográficos
Autores principales: Lai, Zhencheng, Wu, Rongkai, Li, Jiaming, Chen, Xing, Zeng, Linwei, Wang, Xi, Guo, Jingjing, Zhao, Zujin, Sajiki, Hironao, Cui, Sunliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782832/
https://www.ncbi.nlm.nih.gov/pubmed/35064111
http://dx.doi.org/10.1038/s41467-022-28088-z