Dielectricity of a molecularly crowded solution accelerates NTP misincorporation during RNA-dependent RNA polymerization by T7 RNA polymerase

In biological systems, the synthesis of nucleic acids, such as DNA and RNA, is catalyzed by enzymes in various aqueous solutions. However, substrate specificity is derived from the chemical properties of the residues, which implies that perturbations of the solution environment may cause changes in...

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Detalles Bibliográficos
Autores principales: Takahashi, Shuntaro, Matsumoto, Saki, Chilka, Pallavi, Ghosh, Saptarshi, Okura, Hiromichi, Sugimoto, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782835/
https://www.ncbi.nlm.nih.gov/pubmed/35064200
http://dx.doi.org/10.1038/s41598-022-05136-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782835/
https://www.ncbi.nlm.nih.gov/pubmed/35064200
http://dx.doi.org/10.1038/s41598-022-05136-8

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