Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling

Interaction of platelet-derived growth factor (PDGF) isoforms with their receptors results in activation and internalization of receptors, with a concomitant activation of downstream signalling pathways. Ubiquitination of PDGFRs serves as a mark to direct the internalization and sorting of the recep...

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Detalles Bibliográficos
Autores principales: Sarri, Niki, Wang, Kehuan, Tsioumpekou, Maria, Castillejo-López, Casimiro, Lennartsson, Johan, Heldin, Carl-Henrik, Papadopoulos, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782881/
https://www.ncbi.nlm.nih.gov/pubmed/35064336
http://dx.doi.org/10.1007/s00018-022-04128-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782881/
https://www.ncbi.nlm.nih.gov/pubmed/35064336
http://dx.doi.org/10.1007/s00018-022-04128-1

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