Effects of the selective orexin-2 receptor antagonist JNJ-48816274 on sleep initiated in the circadian wake maintenance zone: a randomised trial

The effects of orexinergic peptides are diverse and are mediated by orexin-1 and orexin-2 receptors. Antagonists that target both receptors have been shown to promote sleep initiation and maintenance. Here, we investigated the role of the orexin-2 receptor in sleep regulation in a randomised, double...

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Detalles Bibliográficos
Autores principales: Revell, Victoria L., della Monica, Ciro, Mendis, Jeewaka, Hassanin, Hana, Halter, Robin J., Chaplan, Sandra R., Dijk, Derk-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782905/
https://www.ncbi.nlm.nih.gov/pubmed/34628482
http://dx.doi.org/10.1038/s41386-021-01175-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782905/
https://www.ncbi.nlm.nih.gov/pubmed/34628482
http://dx.doi.org/10.1038/s41386-021-01175-3

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