Loss of imprinting of the Igf2-H19 ICR1 enhances placental endocrine capacity via sex-specific alterations in signalling pathways in the mouse

Imprinting control region (ICR1) controls the expression of the Igf2 and H19 genes in a parent-of-origin specific manner. Appropriate expression of the Igf2-H19 locus is fundamental for normal fetal development, yet the importance of ICR1 in the placental production of hormones that promote maternal...

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Detalles Bibliográficos
Autores principales: Aykroyd, Bethany R. L., Tunster, Simon J., Sferruzzi-Perri, Amanda N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783045/
https://www.ncbi.nlm.nih.gov/pubmed/34982814
http://dx.doi.org/10.1242/dev.199811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783045/
https://www.ncbi.nlm.nih.gov/pubmed/34982814
http://dx.doi.org/10.1242/dev.199811

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