The Rate-limiting Step of DNA Synthesis by DNA Polymerase Occurs in the Fingers-closed Conformation

DNA polymerases maintain genomic integrity by copying DNA with high fidelity, part of which relies on the polymerase fingers opening-closing transition, a series of conformational changes during the DNA synthesis reaction cycle. Fingers opening and closing has been challenging to study, mainly due t...

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Detalles Bibliográficos
Autores principales: Evans, Geraint W., Craggs, Timothy, Kapanidis, Achillefs N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783057/
https://www.ncbi.nlm.nih.gov/pubmed/34929202
http://dx.doi.org/10.1016/j.jmb.2021.167410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783057/
https://www.ncbi.nlm.nih.gov/pubmed/34929202
http://dx.doi.org/10.1016/j.jmb.2021.167410

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