Cargando…

Narciclasine targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells

STAT3 is constitutively activated in multiple malignant tumors. Compared with regular estrogen receptor (ER)-positive breast cancers, the patients with tamoxifen-resistant breast cancers often exhibit higher levels of STAT3 phosphorylation. Narciclasine (Nar) possesses strong inhibiting effects agai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lv, Chao, Huang, Yun, Huang, Rui, Wang, Qun, Zhang, Hongwei, Jin, Jinmei, Lu, Dong, Zhou, Yudong, Shen, Yunheng, Zhang, Weidong, Luan, Xin, Liu, Sanhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783118/ https://www.ncbi.nlm.nih.gov/pubmed/35118192 http://dx.doi.org/10.1016/j.omto.2021.12.025

Ejemplares similares

Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction
por: Huang, Rui, et al.
Publicado: (2021)

Conversion of Natural Narciclasine to Its C-1 and C-6 Derivatives and Their Antitumor Activity Evaluation: Some Unusual Chemistry of Narciclasine †
por: Goulart Stollmaier, Juana, et al.
Publicado: (2022)

Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis
por: Kong, Yi, et al.
Publicado: (2023)

Narciclasine attenuates sepsis-induced myocardial injury by modulating autophagy
por: Tang, Rong, et al.
Publicado: (2021)

Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle
por: Julien, Sofi G., et al.
Publicado: (2017)

Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips
por: Na, Xiaofan, et al.
Publicado: (2011)

Narciclasine, an isocarbostyril alkaloid, has preferential activity against primary effusion lymphoma
por: Gopalakrishnan, Ramakrishnan, et al.
Publicado: (2020)

Design and Synthesis of C-1 Methoxycarbonyl Derivative of Narciclasine and Its Biological Activity
por: Habaz, Lihi, et al.
Publicado: (2022)

Narciclasine improves outcome in sepsis among neonatal rats via inhibition of calprotectin and alleviating inflammatory responses
por: Kingsley, Manoj Kumar, et al.
Publicado: (2020)

Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
por: Jin, Jinmei, et al.
Publicado: (2022)

Inhibition of STAT3 enhances sensitivity to tamoxifen in tamoxifen-resistant breast cancer cells
por: Moon, Seo Yun, et al.
Publicado: (2021)

Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway
por: Yuan, Yunfeng, et al.
Publicado: (2021)

Narciclasine attenuates LPS-induced acute lung injury in neonatal rats through suppressing inflammation and oxidative stress
por: Duan, Qingning, et al.
Publicado: (2020)

Narciclasine, a novel topoisomerase I inhibitor, exhibited potent anti-cancer activity against cancer cells
por: Wang, Meichen, et al.
Publicado: (2023)

Dracorhodin targeting CMPK2 attenuates inflammation: A novel approach to sepsis therapy
por: Zhang, Wendan, et al.
Publicado: (2023)

Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti-inflammatory activities in vitro and in vivo
por: Fuchs, Simone, et al.
Publicado: (2015)

A retrospective cohort study of tamoxifen versus surgical treatment for ER-positive gynecomastia
por: He, Weili, et al.
Publicado: (2023)

Loss of ZIP facilitates JAK2-STAT3 activation in tamoxifen-resistant breast cancer
por: Zhu, Ning, et al.
Publicado: (2020)

Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino‐terminal domain
por: Hua, Yaping, et al.
Publicado: (2018)

Distinctive effect on nerve growth factor-induced PC12 cell neurite outgrowth by two unique neolignan enantiomers from Illicium merrillianum
por: Tian, Xinhui, et al.
Publicado: (2015)

Molecular mechanisms of ferroptosis and its antitumor applications in natural products: Ferroptosis and applications in natural products
por: Yu, Dianping, et al.
Publicado: (2023)

Polymer chimera of stapled oncolytic peptide coupled with anti-PD-L1 peptide boosts immunotherapy of colorectal cancer
por: Lu, Lu, et al.
Publicado: (2022)

Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid
por: Li, Yuanyuan, et al.
Publicado: (2016)

Estrogen receptor variant ER‐α36 promotes tamoxifen agonist activity in glioblastoma cells
por: Qu, Chao, et al.
Publicado: (2019)

Erratum: Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid
por: Li, Yuanyuan, et al.
Publicado: (2016)

Correction for: Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid
por: Li, Yuanyuan, et al.
Publicado: (2023)

The pathogenesis and potential therapeutic targets in sepsis
por: Zhang, Wendan, et al.
Publicado: (2023)

IARC on tamoxifen.
Publicado: (1996)

Tamoxifen evolution
por: Howell, A., et al.
Publicado: (2023)

Tamoxifen inhibits cell proliferation by impaired glucose metabolism in gallbladder cancer
por: Huang, Shuai, et al.
Publicado: (2019)

The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination
por: Jin, Jinmei, et al.
Publicado: (2020)

Integrated transcriptomic and metabolomic profiles reveal the protective mechanism of modified Danggui Buxue decoction on radiation-induced leukopenia in mice
por: Chen, Wei, et al.
Publicado: (2023)

Luminal Breast Cancer Cell Lines Overexpressing ZNF703 Are Resistant to Tamoxifen through Activation of Akt/mTOR Signaling
por: Zhang, Xi, et al.
Publicado: (2013)

Resuming Sensitivity of Tamoxifen-Resistant Breast Cancer Cells to Tamoxifen by Tetrandrine
por: Wang, Yuntao, et al.
Publicado: (2021)

STAT3 mediates resistance of CD44(+)CD24(−/low) breast cancer stem cells to tamoxifen in vitro
por: Wang, Xiaoyan, et al.
Publicado: (2012)

Targeting the IL-6/STAT3 Signalling Cascade to Reverse Tamoxifen Resistance in Estrogen Receptor Positive Breast Cancer
por: Tsoi, Ho, et al.
Publicado: (2021)

Disruption of the ER-α36-EGFR/HER2 Positive Regulatory Loops Restores Tamoxifen Sensitivity in Tamoxifen Resistance Breast Cancer Cells
por: Yin, Li, et al.
Publicado: (2014)

Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development
por: Ford, Benjamin M., et al.
Publicado: (2016)

Emerging protein degradation strategies: expanding the scope to extracellular and membrane proteins
por: Lin, Jiayi, et al.
Publicado: (2021)

Tamoxifen and the Singing Voice
por: Herxheimer, Andrew
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_18mn1e6l4mb811add707co7unl