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Statistics or biology: the zero-inflation controversy about scRNA-seq data
Researchers view vast zeros in single-cell RNA-seq data differently: some regard zeros as biological signals representing no or low gene expression, while others regard zeros as missing data to be corrected. To help address the controversy, here we discuss the sources of biological and non-biologica...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783472/ https://www.ncbi.nlm.nih.gov/pubmed/35063006 http://dx.doi.org/10.1186/s13059-022-02601-5 |