A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro

BACKGROUND: Alzheimer’s disease (AD), the most common form of dementia, is a progressive neurodegenerative disorder that mainly affects older adults. One of the pathological hallmarks of AD is abnormally aggregated Tau protein that forms fibrillar deposits in the brain. In AD, Tau pathology correlat...

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Detalles Bibliográficos
Autores principales: Aillaud, Isabelle, Kaniyappan, Senthilvelrajan, Chandupatla, Ram Reddy, Ramirez, Lisa Marie, Alkhashrom, Sewar, Eichler, Jutta, Horn, Anselm H. C., Zweckstetter, Markus, Mandelkow, Eckhard, Sticht, Heinrich, Funke, Susanne Aileen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783508/
https://www.ncbi.nlm.nih.gov/pubmed/35063014
http://dx.doi.org/10.1186/s13195-022-00959-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783508/
https://www.ncbi.nlm.nih.gov/pubmed/35063014
http://dx.doi.org/10.1186/s13195-022-00959-z

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