Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish

Myosin heavy chain 7 (MYH7) is a major causative gene for hypertrophic cardiomyopathy, but the affected signaling pathways and therapeutics remain elusive. In this research, we identified ventricle myosin heavy chain like (vmhcl) as a zebrafish homolog of human MYH7, and we generated vmhcl frameshif...

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Detalles Bibliográficos
Autores principales: Bu, Haisong, Ding, Yonghe, Li, Jiarong, Zhu, Ping, Shih, Yu-Huan, Wang, Mingmin, Zhang, Yuji, Lin, Xueying, Xu, Xiaolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783688/
https://www.ncbi.nlm.nih.gov/pubmed/34935644
http://dx.doi.org/10.1172/jci.insight.154215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783688/
https://www.ncbi.nlm.nih.gov/pubmed/34935644
http://dx.doi.org/10.1172/jci.insight.154215

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