Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and humans

Inhibitors of the renin-angiotensin system (RAS) are widely used to treat hypertension. Using mice harboring fluorescent cell lineage tracers, single-cell RNA-Seq, and long-term inhibition of RAS in both mice and humans, we found that deletion of renin or inhibition of the RAS leads to concentric th...

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Detalles Bibliográficos
Autores principales: Watanabe, Hirofumi, Martini, Alexandre G., Brown, Evan A., Liang, Xiuyin, Medrano, Silvia, Goto, Shin, Narita, Ichiei, Arend, Lois J., Sequeira-Lopez, Maria Luisa S., Gomez, R. Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783690/
https://www.ncbi.nlm.nih.gov/pubmed/34762601
http://dx.doi.org/10.1172/jci.insight.154337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783690/
https://www.ncbi.nlm.nih.gov/pubmed/34762601
http://dx.doi.org/10.1172/jci.insight.154337

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