Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms

The programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway is a potent inhibitory pathway involved in immune regulation and is a potential therapeutic target in transplantation. In this study, we show that overexpression of PD-1 on T cells (PD-1 Tg) promotes allograft tolerance in a fully...

Descripción completa

Detalles Bibliográficos
Autores principales: Borges, Thiago J., Murakami, Naoka, Lape, Isadora T., Gassen, Rodrigo B., Liu, Kaifeng, Cai, Songjie, Daccache, Joe, Safa, Kassem, Shimizu, Tetsunosuke, Ohori, Shunsuke, Paterson, Alison M., Cravedi, Paolo, Azzi, Jamil, Sage, Peter T., Sharpe, Arlene H., Li, Xian C., Riella, Leonardo V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783692/
https://www.ncbi.nlm.nih.gov/pubmed/34752418
http://dx.doi.org/10.1172/jci.insight.142909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783692/
https://www.ncbi.nlm.nih.gov/pubmed/34752418
http://dx.doi.org/10.1172/jci.insight.142909

Ejemplares similares