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Endoscopic ultrasound in the monitoring of the intestinal allograft
OBJECTIVE: Chronic rejection (CR) of the small intestinal allograft includes mucosal fibrosis, bowel thickening and arteriopathy in the outer wall layers and the mesentery. CR lacks non-invasive markers and reliable diagnostic methods. We evaluated endoscopic ultrasound (EUS) as a novel approach for...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783822/ https://www.ncbi.nlm.nih.gov/pubmed/35058273 http://dx.doi.org/10.1136/bmjgast-2021-000792 |
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author | Oltean, Mihai Hedenström, Per Varkey, Jonas Herlenius, Gustaf Sadik, Riadh |
author_facet | Oltean, Mihai Hedenström, Per Varkey, Jonas Herlenius, Gustaf Sadik, Riadh |
author_sort | Oltean, Mihai |
collection | PubMed |
description | OBJECTIVE: Chronic rejection (CR) of the small intestinal allograft includes mucosal fibrosis, bowel thickening and arteriopathy in the outer wall layers and the mesentery. CR lacks non-invasive markers and reliable diagnostic methods. We evaluated endoscopic ultrasound (EUS) as a novel approach for monitoring of the intestinal allograft with respect to CR. DESIGN: In intestinal graft recipients, EUS and enteroscopy with ileal mucosal biopsy were performed via the ileostomy. At EUS, the wall thickness of the intestinal graft was measured in standard mode, whereas the resistive index (RI) of the supplying artery was assessed in pulsed Doppler mode. At enteroscopy, the intestinal mucosa was assessed. Findings were compared with histopathology and clinical follow-up. RESULTS: EUS was successfully performed in all 11 patients (adequate clinical course (AC) n=9; CR n=2) after a median interval of 1537 days (range: 170–5204), post-transplantation. The total diameter of the wall (layer I–V) was comparable in all patients. Meanwhile, the diameter of the outermost part (layer IV–V; that is, muscularis propria–serosa) was among the two CR patients (range: 1.3–1.4 mm) in the upper end of measurements as compared with the nine AC patients (range: 0.5–1.4 mm). The RI was >0.9 in both CR patients, while the RI was ≤0.8 in all AC patients. Both CR patients had abnormal findings at enteroscopy and histopathology and deceased during follow-up. CONCLUSION: EUS is a promising tool providing detailed information on the intestinal graft morphology and rheology, which may be used for assessment of potential CR in long-term follow-up of intestinal allograft recipients. |
format | Online Article Text |
id | pubmed-8783822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-87838222022-02-04 Endoscopic ultrasound in the monitoring of the intestinal allograft Oltean, Mihai Hedenström, Per Varkey, Jonas Herlenius, Gustaf Sadik, Riadh BMJ Open Gastroenterol Intestinal Failure OBJECTIVE: Chronic rejection (CR) of the small intestinal allograft includes mucosal fibrosis, bowel thickening and arteriopathy in the outer wall layers and the mesentery. CR lacks non-invasive markers and reliable diagnostic methods. We evaluated endoscopic ultrasound (EUS) as a novel approach for monitoring of the intestinal allograft with respect to CR. DESIGN: In intestinal graft recipients, EUS and enteroscopy with ileal mucosal biopsy were performed via the ileostomy. At EUS, the wall thickness of the intestinal graft was measured in standard mode, whereas the resistive index (RI) of the supplying artery was assessed in pulsed Doppler mode. At enteroscopy, the intestinal mucosa was assessed. Findings were compared with histopathology and clinical follow-up. RESULTS: EUS was successfully performed in all 11 patients (adequate clinical course (AC) n=9; CR n=2) after a median interval of 1537 days (range: 170–5204), post-transplantation. The total diameter of the wall (layer I–V) was comparable in all patients. Meanwhile, the diameter of the outermost part (layer IV–V; that is, muscularis propria–serosa) was among the two CR patients (range: 1.3–1.4 mm) in the upper end of measurements as compared with the nine AC patients (range: 0.5–1.4 mm). The RI was >0.9 in both CR patients, while the RI was ≤0.8 in all AC patients. Both CR patients had abnormal findings at enteroscopy and histopathology and deceased during follow-up. CONCLUSION: EUS is a promising tool providing detailed information on the intestinal graft morphology and rheology, which may be used for assessment of potential CR in long-term follow-up of intestinal allograft recipients. BMJ Publishing Group 2022-01-20 /pmc/articles/PMC8783822/ /pubmed/35058273 http://dx.doi.org/10.1136/bmjgast-2021-000792 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Intestinal Failure Oltean, Mihai Hedenström, Per Varkey, Jonas Herlenius, Gustaf Sadik, Riadh Endoscopic ultrasound in the monitoring of the intestinal allograft |
title | Endoscopic ultrasound in the monitoring of the intestinal allograft |
title_full | Endoscopic ultrasound in the monitoring of the intestinal allograft |
title_fullStr | Endoscopic ultrasound in the monitoring of the intestinal allograft |
title_full_unstemmed | Endoscopic ultrasound in the monitoring of the intestinal allograft |
title_short | Endoscopic ultrasound in the monitoring of the intestinal allograft |
title_sort | endoscopic ultrasound in the monitoring of the intestinal allograft |
topic | Intestinal Failure |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783822/ https://www.ncbi.nlm.nih.gov/pubmed/35058273 http://dx.doi.org/10.1136/bmjgast-2021-000792 |
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