Cross-presentation of a TAP-independent signal peptide induces CD8 T immunity to escaped cancers but necessitates anchor replacement

Cancer cells frequently display defects in their antigen-processing pathway and thereby evade CD8 T cell immunity. We described a novel category of cancer antigens, named TEIPP, that emerge on cancers with functional loss of the peptide pump TAP. TEIPPs are non-mutated neoantigens despite their ‘sel...

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Detalles Bibliográficos
Autores principales: Marijt, Koen A., Griffioen, Lisa, Blijleven, Laura, van der Burg, Sjoerd. H., van Hall, Thorbald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783882/
https://www.ncbi.nlm.nih.gov/pubmed/34142235
http://dx.doi.org/10.1007/s00262-021-02984-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783882/
https://www.ncbi.nlm.nih.gov/pubmed/34142235
http://dx.doi.org/10.1007/s00262-021-02984-7

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