Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells

The use of two inhibitors of Mek1/2 and Gsk3β (2i) promotes the generation of mouse diploid and haploid embryonic stem cells (ESCs) from the inner cell mass of biparental and uniparental blastocysts, respectively. However, a system enabling long-term maintenance of imprints in ESCs has proven challe...

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Detalles Bibliográficos
Autores principales: Zhang, Hongling, Li, Yuanyuan, Ma, Yongjian, Lai, Chongping, Yu, Qian, Shi, Guangyong, Li, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783938/
https://www.ncbi.nlm.nih.gov/pubmed/34865203
http://dx.doi.org/10.1007/s13238-021-00890-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783938/
https://www.ncbi.nlm.nih.gov/pubmed/34865203
http://dx.doi.org/10.1007/s13238-021-00890-3

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